Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega−3 polyunsaturated fatty acids

Polyunsaturated fatty acids in normal human blood.

Information on the fatty acid composition of human blood has been fragmentary and conflicting (1,2). Wilson and Hansen (3) have reported unsaturated fatty acids in human plasma and suggested an average iodine number of 108. In 1937, Brown and Hansen (4) showed differences in the amounts of linoleic and arachidonic acids in sera of normal and eczematous children, and later Brown and others (5) d...

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.

BACKGROUND Abnormally elevated blood pressure is the most prevalent risk factor for cardiovascular disease. The large-conductance, voltage- and Ca2+-dependent K+ (BK) channel has been proposed as an important effector in the control of vascular tone by linking membrane depolarization and local increases in cytosolic Ca2+ to hyperpolarizing K+ outward currents. However, the BK channel may also a...

Overall and Abdominal Obesity Are Inversely Associated With Plasma n-3 Polyunsaturated Fatty Acids in Iranian Adults

Background: Obesity is a common health problem associated with a number of diseases, such as hypertension, cardiovascular disease, hyperlipidemia, diabetes, gout, gall bladder and liver disease, cancer, and depression. The prevalence of obesity is dramatically increasing around the world, especially in the Asia Pacific region.  omega-3 is a type of polyunsaturated fatty acids that have several ...

Metabolic Effects of Polyunsaturated Fatty Acids in Chickens: A Review

Chicken has been used as a suitable model for lipid metabolism studies, because dietary modifications especially dietary fat type can change chicken body composition. Fats act as a condense source of energy and certain fatty acids such as polyunsaturated fatty acids (PUFAs) are required for both animal and human health. The n-3 PUFAs, especially, eicosapentaenoic acid (EPA) and docosahexaenoic ...

Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring